Scotland and Edinburgh winger Darcy Graham requires groin surgery and is likely to miss the rest of the season.
Graham had hoped to return from a quadricep injury in time for last weekend’s Six Nations game against England.
But the 26-year-old’s latest setback rules him out of the championship for the second year running.
Graham is joint-third on Scotland’s all-time try-scoring list with 24 from 39 Tests.
“We really feel for Darcy because he is a player that puts his heart and soul into rugby,” said Edinburgh head coach Sean Everitt, who estimates a “three-to-four month” absence for the back.
“He loves playing for this club while he is a proud Scotsman who takes great pride in representing his country.
“We’ve got every confidence Darcy will work his way back from next week’s surgery with the same drive and determination with which he trains and plays.”
Graham scored five tries at the World Cup but picked up a hip injury in the final pool game against Ireland on 7 October.
He made his Edinburgh comeback in December but managed just four appearances before sustaining the quadricep problem.